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In the absence of GliT, gliotoxin may be alternately reduced by intracellular GSH ( 5 ) leading to a depletion in GSH and cell death/growth arrest and also modification of other cellular proteins leading to inactivation or activity modification ( 6 )

In some embodiments, formulations or compositions described herein provide a constant, sustained, extended, delayed or pulsatile rate of release of an active agent into the inner ear environment and thus avoid any variability in drug exposure in treatment of otic disorders

(Weinh) 8 (8), 2002874

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Medicare and Medicaid coverage also varies by plan formulary and the reason for taking the medication

Gwyer et al., 2019, Vukojevic et al., 2022)