Major clinical trials for semaglutide, including the SUSTAIN series and real-world monitoring of Ozempic users, show that mood disorders occur in fewer than 2% of patients and are typically mild or transient
They found it easier to resist cravings and cut back on addictive behaviors, particularly around food
J Clin Invest 91(1):301307 Maekawa R, Ogata H, Murase M, Harada N, Suzuki K, Joo E et al (2018) Glucose-dependent insulinotropic polypeptide is required for moderate high-fat diet- but not high-carbohydrate diet-induced weight gain
Yaver & Bilgicli 2021
doi: 10.1073/pnas.1316569111
The use of nalbuphine, a blocker of - and -opioid receptors, also disrupted the effect of GLP-1RAs on reducing TNF- levels, highlighting the essential role of these opioid receptors in the anti-inflammatory effects mediated by GLP-1RAs