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A randomized, double-blind, placebo-controlled trial in 153 older adults taking the antidepressant citalopram found daily supplementation with 500 g vitamin B 12 , 2 mg of folic acid, and 25 mg of vitamin B6 for one year did not reduce the severity of depressive symptoms but increased the response to drug treatment and helped to prevent symptom relapse (112), suggesting B-vitamin supplementation might provide some benefit as an adjunct therapy

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Each and every cell in our body has the capability to make glutathione on its own according to its metabolic demands. - Shalin Kochar Why Glutathione Levels May Decline Over Time Glutathione demand appears to increase in response to cumulative physiologic stress