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For example, the ethanol-inducible CYP2E1, which is located in the centrilobular hepatocytes, effectively catalyzes the centrilobular hepatotoxicity of acetaminophen, carbon tetrachloride, benzene, and nitrosamines

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The dopamine system is one of the most studied neurotransmitter systems, with dopamine being one of the earliest identified neurotransmitters due in large part to its pivotal role in the reward system, a system often described as being essential to all forms of life

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PubMed CrossRef Ali AM, Martinez R, Al-Jobori H, et al

Moreover, it is well known that IL-1 activates NLRP3 inflammasome via IL-1R-mediated NF-B activation [40]