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Effects are modest

doi: 10.1016/j.cophys.2021.01.003 51 HuangYAPereiraERoperSD

Some evidence suggest supplemental melatonin, a sleep-wake (circadian) hormone, may improve unwanted hair growth, insulin levels, levels of male hormones, blood lipid levels, and menstrual regularity among women with polycystic ovary syndrome

It has been shown that patients with major depressive disorder have systemic and localized disorders of glucose metabolism throughout the course of the disease, disrupting various processes such as glucose uptake, glycoprotein transport, glycolysis, the tricarboxylic acid cycle and oxidative phosphorylation

The study found people taking these drugs had a four times greater likelihood of having an eye stroke