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Najafipour, H

Other companies, including Terns Pharmaceuticals (TERN-601), Structure Therapeutics (GSBR-1290), and Viking Therapeutics, have oral GLP-1 programs at earlier stages of development, but none has reached Phase 3 or generated the depth of clinical data available for orforglipron

Aldosterone is involved in the pathogenesis of obesity-related glomerulopathy through activation of Wnt/-catenin signaling in podocytes

They are likely multifactorial and may involve delayed gastric emptying, altered intestinal fluid secretion, and central nervous system effects on gut function

Diabetes Obesity and Metabolism, 26(3), pp

Real-world treatment gaps are expected to make follow-up support more visible