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CrAT deficiency leads to accumulating acetyl-CoA, which exerts an allosteric inhibiting effect on pyruvate dehydrogenase (PDH), a rate-limiting enzyme for pyruvate entry into the Krebs cycle

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This makes hCG the preferred tool in preclinical models requiring sustained LHCGR stimulation rather than pulsatile receptor engagement

For that reason, we initially confirmed that our clone secreted slime using direct observations 53 and was able to glide in an established clumping assay (refs

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