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In contrast to GIP, GLP-1 was found to retain its insulinotropic effect in patients, and this fact provides part of the background for the clinical use of GLP-1 receptor agonists in diabetes treatment

Nephron 1991;57(3):306-313

Some resolve completely

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2022 May 1;31(3):235-243

Therefore, microsphere sustained-release technology is being utilized to enable GLP-1 drugs to be released slowly and continuously, or GLP-1 molecules are being modified and optimized through structural modifications to develop GLP-1 RAs with longer half-lives