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C (101 MHz, CDCl 3 ): 170.176 (C 2), 135.18 (d, J = 2.8 Hz, CH 6), 133.57 (d, J = 9.8 Hz, CH 12), 130.59 (d, J = 12.5 Hz, CH 12), 118.10 (d, J = 85.9 Hz, C 6), 38.58 (CH 2 2), 36.56 (CH 2 2), 27.97 (CH 2 2), 27.27 (d, J = 16.5 Hz, CH 2 2), 22.50 (d, J = 50.8 Hz, CH 2 2), 21.83 (d, J = 4.2 Hz, CH 2 2)

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Es fundamental que los pacientes mantengan expectativas realistas y comprendan que los efectos completos de estos medicamentos requieren tiempo, titulacin gradual hasta la dosis objetivo y adherencia constante al tratamiento