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The 12 mg dose was also associated with reductions in several cardiovascular risk factors , including triglycerides, non-HDL cholesterol, systolic blood pressure and high-sensitivity C-reactive protein

Diabetologia 55:26672676 Xu G, Stoffers DA, Habener JF, Bonner-Weir S (1999) Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats

Some researchers interpret this as "the medication is not for me" rather than recognizing it as a timing problem specific to escalation

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Eli Lilly makes both the dual-agonist and triple-agonist drugs