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Patients with diabetes may need closer glucose monitoring and clinician-directed adjustments to other diabetes medicines

No direct head-to-head trial has been conducted, so these comparisons are drawn from separate trials with different populations and durations

LEXINGTON, Ky

30, 2026 An earlier version of this story mistakenly said that the drug tirzepatide blocks a hormone called GIP

Is retatrutide (LY3437943), a GLP-1, GIP, and glucagon receptor agonist a step forward in the treatment of diabetes and obesity

As part of our weight management services, we prescribe medications such as semaglutide GLP-1 and Zepbound to help patients achieve and maintain a healthy weight, when appropriate