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March 2018

That the data did not exist when the label was written

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When compared to GLP-1 receptor agonists alone, DA-CH5 had greater neuroprotection than exendin-4 [110], whilst DA-CH3 protected dopaminergic neurons, reduced inflammation, and MPTP-induced motor impairment to a greater extent than liraglutide [115]

In the PIONEER PLUS trial, for individuals with type 2 diabetes, a daily dose of 50 mg oral semaglutide achieved a weight loss of 9.8% over a continuous 68-week study period compared to 5.4% weight loss with a daily dose of 14 mg semaglutide