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Currently the preferred delivery systems are the parenteral or local route, as miRNAs have reduced intestinal absorption via the oral route [78]

Meta-analyses indicate that GLP-1RAs generally reduce HOMA-IR and improve fasting blood glucose and 2 h OGTT levels in the PCOS population (78)

10.2903/j.efsa.2015.4149 24 El-HakN

The decision to continue, pause, or modify your GLP-1 therapy should always be made in partnership with your medical team, weighing the benefits of sustained weight loss against symptom burden

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Gradual tapering over 48 weeks significantly reduces this rebound by allowing hunger hormones to normalize progressively rather than spiking suddenly