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Institutional Review Board Statement This research was approved by the local Ethics Committee (case number 380-59-10106-17-100/290) and by the Directorate of Veterinary (UP/I-322-01/15-01/22)

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Statistical analysis The objective data are expressed as means standard deviation

Persistent hyperglycemia, a hallmark of diabetes and insulin resistance, initiates the Maillard reaction, a non-enzymatic chemical process in which reducing sugars react with amino groups on proteins and lipids, resulting in the formation of AGEs (106)

Prior authorization requirements: Immediate flags signaling whether a medication requires a payer-approved clinical justification form