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Increasing awareness of advanced therapeutic options, growing demand for weight management drugs, and favorable clinical outcomes of GLP-1 receptor agonists over traditional treatments are accelerating adoption

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The SUSTAIN 6 trial found that once-weekly subcutaneous semaglutide reduced the risk of MACE by 26% compared to placebo over a 2-year period

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364 The metabolic reprogramming is characterized by shifting glucose metabolism to aerobic glycolysis, including enhanced cytosolic lactate fermentation and PPP and decreased OXPHOS

The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration