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In December 2025, Eli Lilly announced topline results from the phase-3 TRIUMPH-4 clinical trial evaluating the safety and efficacy of retatrutide in adults with obesity or overweight and knee osteoarthritis, and without diabetes, as an adjunct to healthy diet and physical activity

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Feb 1985;17(1):23-32

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Distribute protein intake across meals rather than consuming it all at once, as this maximizes muscle protein synthesis