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Cannabinoids and multiple sclerosis

These effects are dose-dependent: low to moderate doses mainly enhance adaptive stress responses through mild Nrf2 activation, while higher doses of concentrated alcoholic extracts produce stronger pharmacological effects by directly suppressing NF-B and intensifying Nrf2 activation [33]

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A compound affecting so many biological pathways could easily have subtler harms that small trials (or enthusiastic investigators) might miss

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