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doi: 10.1016/j.foodchem.2020.127850, 74

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Although infusion of long-acting (acyl) GIP into the lateral ventricle decreases body weight and food intake in DIO wildtype (WT) mice, these effects vanish in mice with central nervous system (CNS) loss of Gipr 15

The mechanism appears to involve reduced inflammation markers (C-reactive protein, interleukins) that are elevated in chronic migraine sufferers