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One randomized controlled trial (RCT) found that exenatide (2 mg weekly for 6 weeks), when combined with a nicotine replacement therapy patch, reduced nicotine cravings, withdrawal symptoms, and post-cessation weight gain, and increased nicotine abstinence compared to placebo or nicotine replacement therapy alone, in individuals who had smoked for at least a year and consumed 10 cigarettes daily [21]

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