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Most preclinical trials used weight-adjusted dosing (mg/kg) that doesn't translate directly to fixed human protocols

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doi: 10.1111/dom.13804 36 JendleJBirkenfeldALPolonskyWHSilverRUusinarkausKHansenTet al

Additionally, navigating strict purity requirements adds further pressure, especially in projects demanding controlled conditions and reliable biochemical performance

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