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10.3904/kjim.2017.343 Kor J Internal Med

Patients with gastrointestinal disorders such as Crohns disease, celiac disease, or those who have undergone gastrointestinal surgeries (including gastric bypass) often experience impaired B12 absorption

Likewise, decreased carnitine in muscle, liver and kidney has been found to be a common trait of the insulin resistant state, including diet-induced obesity, genetic diabetes and aging [10]

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The result: softer, easier-to-pass stool, even when motility remains reduced

Supporting this notion, GLP-1 RAs are reported to decrease reactive oxygen species production in endothelial cells, reduce circulating markers of inflammation, and slow atherosclerotic plaque formation by inhibiting the expression of adhesion molecules [43, 52]