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Strictly Research Use Only (RUO)
Hemolytic anemia may be more prevalent in patients with both MTHFR and B12 deficiency
However, development was discontinued in 2007 after the largest Phase IIb trial failed to demonstrate statistically significant weight loss compared to placebo
High doses can cause liver damage or worsen certain medical conditions
They may slightly reduce hunger (since growth hormone can influence appetite signals), but their key effect is improving metabolism and body composition rather than making you eat less
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