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Four weeks of aerobic exercise significantly increased the expression of PGC-1, FNDC5, and Irisin, upregulated the expression of Drp1, Parkin, and LC3B, and decreased the level of Fis1 in the skeletal muscle of aging critical limb ischemia (CLI) mice, which subsequently enhanced mitochondrial fission and mitophagy, decreased the number of Tunnel-positive cells, increased ischemic limb mitochondrial MMP and total ATP production, inhibited skeletal muscle apoptosis, and restored limb function and tissue injury in CLI mice

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Hopkins PN, Toth PP, Ballantyne CM, Rader DJ