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The ligands were further energy minimized using Chem3D (ChemOffice 2002) MM2 energy minimization program

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Applying heat with a warm towel or soaking your feet in warm water can also relax the muscles

Mater Chem Phys 15(181):301311

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GHK-Cu is a naturally occurring copper complex of the tripeptide glycyl-L-histidyl-L-lysine, originally isolated by Loren Pickart from human plasma in 1973. The compound is one of the most extensively characterized small peptides in published research, with documented effects on collagen synthesis, glycosaminoglycan production, and approximately 4,000 human gene expression changes