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The sprays are based on aqueous solutions of the anti-helminthic drug niclosamide, a drug with relatively low water solubility at pH 7 (and hence prohibitively low bioavailability)

Both of these drugs also come with a risk of serious side effects, such as pancreatitis for Januvia and ketoacidosis for Jardiance

The final concentrations of ammonium formate and NEM in the extraction solvent were 2 mM and 5 mM, respectively

Conclusion: Our work enabled us to identify symptomatic male carriers of the factor XII mutation screened in France between 2006 and 2021

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