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In atherosclerotic disease, GLP-1RAs have been shown to attenuate and stabilize development of atherosclerotic plaques through anti-inflammatory mechanisms (inhibition of IL-6 and TNF-, and NF-B), inhibit activation and recruitment of macrophages and prevent vascular remodeling

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While it is unlikely that taking supplements will have an adverse effect on sleep, some limited evidence suggests that certain supplement intake may have a negative impact on sleep quality

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