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AMG 133 functionally inhibits GIP signalling through human and cynomolgus monkey GIPR with similar potency (half maximal inhibitory concentration (IC 50 ) of 42.4 nM and 26.5 nM, respectively), whereas it has more than 20-fold lower potency for inhibition of GIP signalling through rat GIPR (IC 50 = 822 nM) and did not fully antagonize mouse GIPR with concentrations of up to 3 M

L., Taylor, R

Changes noticed in the first few weeks are more likely related to appetite changes, medication adjustment effects , or coincidental disease fluctuation rather than meaningful anti-inflammatory benefit

Bottom line: Diverticulitis does not have to be a barrier to reaching your weight goals, but it does require a smarter, more supervised approach to GLP-1 therapy

The Quebec natural experiment changed that