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Lilly showed in recently announced clinical trial results that patients who switched to orforglipron after losing weight on either Wegovy or Zepbound regained less weight than participants who switched to a placebo

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Key factors influencing stability at room temperature include: Duration of exposure even brief exposure at elevated temperatures can begin to compromise some peptide formulations Ambient temperature UK indoor temperatures can exceed 25C in summer, particularly in cars or near windows [17] Formulation excipients stabilising agents may offer some protection, but this varies by product and is not known for retatrutide Until formal stability data for retatrutide are publicly available and the medicine is licensed, any unplanned room-temperature exposure should be treated with caution and reported to the prescribing team or trial coordinator