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Keywords , weight loss , liver fibrosis , phase 3 clinical trial , metabolic syndrome , non-invasive tests 0 1 INTRODUCTION Metabolic dysfunction-associated steatotic liver disease (MASLD) has become a leading cause of chronic liver disease worldwide, tightly linked to obesity, type 2 diabetes mellitus (T2DM), and other components of the metabolic syndrome [1]

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Wang Y, Chen L, Adu-Frimpong M, Wei C, Weng W, Wang Q, Xu X-M, Yu J (2021) Preparation, in vivo and in vitro evaluation, and pharmacodynamic study of DMY-loaded self-microemulsifying drug delivery system

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Underlying conditions such as hypothyroidism, Cushing's syndrome, PCOS, or obstructive sleep apnoea can blunt weight loss responses and should be investigated if not already excluded

noticeable weight loss by weeks 4-8