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have developed fusion proteins composed of the GH ligand or a GHR antagonist fused to GH-binding protein (GHBP), the extracellular domain of the GHR, which is proteolytically cleaved from the receptor and exists in the circulation (Fig

2011 Sep;38(3):489-501

MAPK-ERK1/2, mitogen-activated protein kinase, extracellular signal-regulated kinase

In vitro cytotoxicity assays using SH-SY5Y (human neuroblastoma), Caco-2 (intestinal permeability), and hCMEC/D3 (human brain endothelial) cells demonstrated that nanoencapsulation significantly reduced the inherent cytotoxicity of free coumarin