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The trade-off researchers weigh is that more frequent stimulation of the ghrelin receptor could, in principle, blunt responsiveness over time a receptor-desensitization concern that is plausible but not well characterized for Ipamorelin specifically

[DOI] [PMC free article] [PubMed] [Google Scholar] 5.Hornberger TA

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Br J Pharmacol 2011;164:37-47

Key discoveries include the impaired development and function of GABAergic interneurons, the complexity of GABA signaling disruptions (e.g., altered synthesis, transport, and receptor function), and the genetic-environmental interactions that amplify neurodevelopmental vulnerabilities