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Emerging role of GLP-1 agonists in obesity: a comprehensive review of randomised controlled trials

8 Studies have also shown semaglutide to be superior to some other weight-loss agents

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Participants who titrated from the lowest starting dose (2mg) generally achieved slightly better outcomes at the 12mg target

Therefore, we engineered a chimeric protein by fusing GLP-1 to an HSA-binding DARPin with a high affinity for albumin that takes advantage of the extended plasma circulation of HSA to develop a long-acting variant of GLP-1

Al-Sabah S, and Donnelly D