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Conversely, loss of IGF2R in malignant cells results in increased IGF-2 binding to IGF1R, increasing proliferation [19]

Relatively common side effects Internal bleeding or itching at the injection site, diarrhea, constipation, headache Severe side effects hypoglycemia, pancreatitis, bowel obstruction, palpitations *Although GLP-1 alone rarely causes hypoglycemia, it has been reported that combined use with insulin or oral hypoglycemic agents can cause severe hypoglycemia

They were later FDA-approved for weight loss in 2014

GLP-1 drugs an acronym for glucagon-like peptide 1 like those listed above curb appetites and increase insulin production in the body, helping those who take them to shed weight

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