Cocaine blocks the reuptake of serotonin across the brain, leading to a strong, broad increase in serotonin activity, while alcohol causes more localized, subtle changes in serotonin, as studied by Scripps Research in Serotonin Receptors and Drug Abuse. L ow serotonin levels are especially significant in addictive behaviors related to compulsive, reward-seeking actions, such as binge drinking, gambling, or drug use, where the brains reward system is hijacked to alleviate emotional discomfort or induce a temporary state of well-being
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Integration with metabolic therapies: since senescent adipose tissue, liver steatosis and visceral fat contribute to metabolic decline, FOXO4-DRI might improve metabolic resilience
It also stimulates the formation of new blood vessels (angiogenesis) through the VEGF pathway, which is how injured tissue gets the nutrients it needs to rebuild
