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They generally have a high water content, which increases urine volume, have an alkalizing effect on urine, increase urinary citrate, and are naturally low in sodium and rich in potassium and magnesium

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Cost-Effectiveness: Larger vial sizes (like 15mg) offer a lower cost-per-milligram, making extended preclinical studies financially viable

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L-citrulline and citrulline malate supplements are generally safe for healthy individuals, and research has used doses of up to 15g/day without serious adverse effects.15 Like any supplement, even the healthiest individuals might experience some nausea, headaches, or gastrointestinal discomfort when beginning a new regimen