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Front Pharmacol 12:643254 Ishii T, Itoh K, Takahashi S, Sato H, Yanagawa T, Katoh Y, Bannai S, Yamamoto M (2000) Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages

BPC-157 triggers a specific chemical signal (Src-Caveolin-1 phosphorylation) that unlocks this enzyme, allowing a controlled release of nitric oxide to start the healing process

The underlying mechanisms of resistance are complex and varied, mainly involving factors such as lack of tumor immune response, depletion and loss of T-cell function, and alterations in relevant genes [118,119,120]

References Abi-Dargham A, Grace A

Absorbance was read at 595 nm using a spectrophotometer

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