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No established DSIP-specific receptor has been identified

Topically applied hydroquinone-containing creams may give rise to accumulation of these compounds, which can cause DNA damage and mutations

Changes in the cellular redox state can alter the oxidation state of metabolic enzymes, resulting in changes in their activity and altered flux through upstream and downstream pathways

The lack of FDA approval also means that definitive safety and efficacy trials are still forthcoming

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