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Hypoxia signaling also interacts with the PI3K-mTOR pathway and plays an important role [508]

Circulating MOTS-c is detectable in humans and declines with age, but no completed human trial of administered MOTS-c has read out

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Gastrointestinal (GI): Nausea is the most common side effect and tends to be dose-dependent

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In conclusion, our findings suggest that exenatide, a drug emerging as an ICP lowering agent in IIH does not adversely impact cognition