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Compared with fulllength TB500, the fragment shares the same peptide sequence (LKKTETQ) but lacks an aldehyde group on the leucine residue, a difference that reduces its molecular weight (889.0 vs 846.97 g/mol) and is proposed to increase stability, prolong halflife, and reduce offtarget interactions

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I will be following the vote and reporting back on what it actually means, not just what the headlines say

This selective signaling behavior allows researchers to examine how peptide fragments can retain specific biological functions while avoiding broader receptor activation

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