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Some samples contained heavy metals including lead and cadmium at levels exceeding USP limits (FDA Safety Communication, 2025)

In other words, the pathways plateau at different points, creating a scenario where more dosage drives further weight loss without proportionally increasing metabolic benefit

Approval timelines typically span 24 weeks, delaying treatment initiation

It adds that health professionals have a key role in identifying and managing the risks associated with unregistered GLP-1 products and should advise patients accordingly

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345,346 GLP-1 may also reduce the expression of cartilage-degrading enzymes by inhibiting the MAPK pathway or activating anti-inflammatory pathways such as PI3K/Akt, thereby alleviating cartilage damage