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Glutathione , a powerful antioxidant naturally produced in the body, is often explored for its potential in treating melasma due to its skin-lightening properties

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36,37 As a result of the activation of stellate cells and a subsequent enhancement in collagen and extracellular matrix synthesis, the space of Disse becomes thickened, so that capillarization develops and the normal fenestrated architecture of the sinusoidal endothelium is lost

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