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Both of them are Hate Sink Green and Mean jerks with no redeeming qualities who were introduced as an Arch-Enemy to leading characters (Bubble Bass for SpongeBob, Squilliam for Squidward)

Xie L, Lu J, Ostenson CG, Xu T, Chen ZW

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Although it entered phase 1 trials in consideration as a treatment of ulcerative colitis, it has not been approved by the US Food and Drug Administration (FDA) for medical use, and data on human subjects is lacking

Blondin DP, Labbe SM, Phoenix S, Guerin B, Turcotte EE, Richard D, et al