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SURMOUNT-1 enrolled people with obesity or overweight and no diabetes, and the weight reduction just kept climbing with the dose: about 15 percent at 5 mg, 19.5 percent at 10 mg, and a frankly striking 20.9 percent at 15 mg over 72 weeks

GIP receptor activation: enhances insulin secretion in a glucose-dependent manner, promotes adipocyte lipid metabolism, and may contribute to central appetite suppression through pathways distinct from GLP-1

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