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When combined, these overlapping side effect profiles may worsen GI tolerability, particularly during the dose escalation phase when tirzepatide GI effects are already at their peak

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Glutathione: Glutathione is a powerful antioxidant that plays a vital role in the body's defense against oxidative stress and free radicals

This is important because it suggests that glucagon receptor activation, when balanced by incretin co-agonism, does not automatically negate glycemic benefit