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In addition, the activity and expression of SLC7A11 is strictly regulated by multiple mechanisms, such as transcription factor 4 (ATF4), nuclear factor erythroid 2related factor 2 (NRF2), ubiquitin BRCA1 (Breast cancer gene 1)-associated protein-1 (BAP1), the SWI/SNF complex, and rapamycin complex 1 (mTORC1) (51), through which the expression of SLC7A11 can be upregulated to enhance the antioxidant defense of cells and inhibit the occurrence of ferroptosis ( Figure 1B )

This sustained action leads to a more consistent elevation of GH levels without the sharp peaks and troughs associated with short-acting GHRH analogs

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This phenomenon can be attributed to the formation of a robust intermetallic phase between Cu and Al, which hinders ion release, explaining the weak antibacterial activity of these alloy coatings

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