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GM imbalance, resulting from factors such as aging, hormonal shifts, or dietary habits, promotes the progression of OP through the perturbation of these networks

Additionally, SIRT1 suppresses macrophage-activating protein-1 (AP-1) transcriptional activity, by deacetylating PGC-1, thereby exerting anti-inflammatory effects

Using a Xenopus egg-extract model, which uncouples DNA repair from gene transcription 26 , we determined that IDH1 inhibition increased DSB formation and decreased HR, which was rescued by KG (Fig

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Prevalence and predictors of suboptimal glycemic control among patients with type 2 diabetes mellitus in northern Thailand: a hospital-based cross-sectional control study