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Hernndez, Lpez-Snchez, and Rendn-Ramrez (2016) Most first pass metabolism occurs in the liver [49, 55] and the rate-limiting step is the oxidation of ethanol to acetaldehyde

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Figure 1 5 Non-alcoholic cofactors contributing to HBV-associated HCC Alcohol can be viewed as one of several key cofactors that modify the natural history of CHB infection, alongside metabolic syndrome, obesity, and viral coinfections