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Oral contraceptives: the semaglutide DDI study showed a slight delay in ethinylestradiol and levonorgestrel Tmax but no reduction in AUC, so no change in contraceptive efficacy is expected per the FDA label

Moreover, it is crucial to gather more information on fracture-related outcomes associated with GLP-1Ra use considering body composition alterations

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This article summarises available evidence, highlights gaps and proposes practical approaches for safe, effective switching

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The data generated from these studies aims to contribute to the broader scientific knowledge base, potentially leading to new treatments or medical advancements