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131 Nevertheless, most of the evidence gathered to date was derived from smaller mechanistic studies, and the few large randomized controlled trials have not shown a significant mortality benefit of using these agents

Additionally, the mechanical stress experienced by the TMJ and the knee differs, with the TMJ being subjected to complex movements and loads during jaw function, while the knee experiences primarily compressive and shear forces

Researchers also use it in comparative studies examining how copper-binding peptides modulate gene expression profiles

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