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This crosslinking of collagen and elastin is carried out by an enzyme known as lysyl oxidase (LOX), which is induced by hypoxia (via HIF-1) and oncogenic signaling, leading to invasion and therapy resistance

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The synthesis and the molecular structure of the BG-linker and CA-linker 53 moieties after coupling is shown in Supplementary Note 1

Given the high population prevalence of PCOS, urgent further studies are needed to understand the complex associations between androgen metabolism, insulin signalling, metabolic risk and malignancy in this patient cohort